Endocrine Abstracts

IntroductionUnilateral PA can be cured with unilateral adrenalectomy. Adrenal vein sampling (AVS) is the current reference test to identify unilateral PA, but it is invasive and technically-difficult. 11C-metomidate PET-CT offers a non-invasive alternative to AVS. We compared the accuracy of AVS and PET-CT in identifying patients with unilateral surgically-curable PA.MethodsIn this prospective multi-centre cl...

Objective: Assessment of the health status in a population from a territory with apparently normal iodine intake may take in consideration the incidence of goiter as a mass pathologic process. Considering goiter as a result of both endogenous and exogenous factors, the study of its incidence and correlations with potentially goitrogens represents a prophylactic medical activity. Use of the term ‘paraendemic’ for a certain territory does not justify a ‘relaxation...

Introduction: Involvement of growth hormone in the maturation and function of the ovary is proved by a series of clinical observations.Scope: Assessing serum levels of IGF1 as a marker of GH activity correlated to age of onset of menarche and menopause.Method: The study groups consisted of 41 patients (group 1) with GH deficiency diagnosed before the age of 8 years and a group of 18 adult patients with pituitary dwarfism who had ea...

Pro-inflammatory cytokines activate the hypothalamic pituitary adrenal (HPA) axis but chronic inflammatory diseases such as Rheumatoid Arthritis (RA) do not. The axis is subtly subnormal despite nocturnal cytokine peaks. This poses the question ‘Why does the endocrine dog not bark in the cytokine night?’. Is this chronic stress adaptation similar to that seen with restraint when the normotypic stressor is reduced with decreased parvocellular CRH mRNA, a compensatory ...

Concerns have been raised that undergraduate medical education in Endocrinology/Diabetes (E&D) is not preparing students adequately for clinical practice. This project assessed trainer perceptions of the delivered D&E curriculum and identified areas for improvement. We surveyed E&D consultants at the 12 hospitals which accept students from our medical school using an online questionnaire. Emails were sent to 50 consultants. The response rate was 46% (23/50 recipien...

Background: Bariatric surgery remains the most effective method of weight loss and can result in partial or complete resolution of multiple obesity-related comorbidities. Bariatric surgery should be performed in conjunction with a comprehensive preoperative assessment and a follow-up plan consisting of nutritional, behavioral, and medical programs. The bariatric surgical procedures are associated with significant long-term complications, primarily malnutrition.<p class="ab...

In 2010 non-communicable diseases were shown to be the most important cause of mortality worldwide on the WHO global status report, with diabetes the 4th most common disease causing death. Type 1 diabetes Mellitus (T1DM) is the most common form of diabetes in children and young people. There is a paucity of data regarding T1DM in children in West Africa, in particular in The Gambia.Aim: To explore the clinical presentation and outcome of children with T1...

In 1547 Henry VIII died, and was succeeded by his young son from his marriage to Jane Seymour; the boy was only 9 years old, and became Edward VI. However, he was a sickly child, and only survived to the age of 15 years, probably dying of TB. With no living male heir, there was an attempt at continuing with a Protestant monarch, but this lasted only 9-days with the unfortunate Lady Jane Grey. The crown then fell to Mary, the child of the marriage of Henry to Catherine of Arago...

In 1807, the Hunterian museum, the first public museum in Scotland, opened at the University of Glasgow. Its contents were bequeathed by William Hunter, a graduate of the university, and included, as well as anatomy specimens, books, coins, paintings, natural history specimens, ‘curiosities from the South Seas’, minerals, fossils and so forth. A letter of 1809 stated ‘Hunter’s museum has been here for some time and drawn a considerable number of students to...

Introduction: The European Registries for Rare Endocrine Conditions (EuRRECa) was created in collaboration with the European Reference Network on Rare Endocrine Conditions (Endo-ERN), the European Society for Paediatric Endocrinology and the European Society of Endocrinology to support the needs of the endocrine community.Aim: To describe the patient population and data entered in the EuRRECa Core Registry between June 2019 and December 2021.<p class...